Lars Malmstroem, Ph.D.

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About f1000

F1000 is a scientific literature awareness tool where selected researchers review and comment on current papers. I'm an associate member and hence can post reviews together with Ruedi Aebersold who is a full member. Please find my posts below.

2010-04-27: Evolution of MRSA during hospital transmission and intercontinental spread.

Genome sequencing of methicillin-resistant Staphylococcus aureus (MRSA) from multiple temporal and spatial isolates has revealed information about infection paths and mutation rates.

Antibiotic-resistant bacteria are a growing global health problem. An obvious strategy to prevent the spread of such strains is to reduce transmission between individuals. This ultimately relies on our understanding of the transmission paths. In this paper, multiple strains were sequenced and single-nucleotide polymorphisms (SNPs) were analyzed in great detail generating a high-resolution dendrogram. The study demonstrates how genome sequencing of bacterial isolates (isolated across time and space) of a particular strain of MRSA, TW20, provides a high-resolution map on how bacteria spread between patients at the same hospital and provides information about intercontinental spread. The applied technology lays the foundation for investigating how the bacteria are spread long after the outbreak has occurred provided that a sufficient number of isolates were collected and catalogued.

Check out the F1000 site for more information (need subscription) or pubmed for complete reference information.

2010-01-13: Structure and mechanisms of a protein-based organelle in Escherichia coli.

In this study, X-ray structures of four microcompartment proteins that are the components of the protein-based organelle capsule explain how bent conformations are achieved and reveal an active gating function.

There is growing evidence that bacteria are, in fact, not devoid of internal compartmentalization but are rather highly organized. For example, bacterial proteins are to a large extent organized in protein complexes {1} and are sometimes localized to specific regions of the cytosol {2}; in addition, there is also evidence for protein-encapsulated organelles (see ref {3}, on which Ruedi Aebersold is an author). In this paper, Tanaka and colleagues reveal how one of the shell proteins has a bent conformation which allows these microcompartments to close. They also show that there is an active gate that presumably regulates the in- and out-flow of various molecular species. This paper adds to the evidence that the proteomes of bacteria are highly structured and compartmentalized.

References: {1} Kuehner et al. Science 2009, 326:1235-40 [PMID:16081736]. {2} Shapiro et al. Science 2009, 326:1225-8 [PMID:19965466]. {3} Kerfeld et al. Science 2005, 309:936-8 [PMID:19965468].

Check out the F1000 site for more information (need subscription) or pubmed for complete reference information.